What is cell carcinoma? Squamous cell carcinoma is more malignant than basal cell carcinoma. It grows faster and has a wide range of damage. It can damage the eyelids, eyeballs, orbits, sinuses, and face.

　　Squamous cells Carcinoma may exhibit keratinization, keratinized bead formation, and/or intercellular bridges. These characteristics vary with the degree of differentiation. This feature is evident in well-differentiated tumors, but only partially visible in poorly differentiated tumors. Papillary SCC. Some tumors located in the proximal bronchi may show outward growth and intrabronchial growth. Sometimes only very limited intraepithelial spread is seen without infiltration, but in most cases there is infiltration. Transparent cell type SCC. It is mainly or almost entirely composed of cells with clear cytoplasm. This type needs to be distinguished from large cell carcinoma, lung adenocarcinoma with extensive clear cell changes, and renal metastatic clear cell carcinoma.

　　Small cell type SCC is a poorly differentiated squamous cell carcinoma. Small tumor cells retain the morphological characteristics of non-small cell carcinoma and show localized squamous differentiation. This type must be distinguished from compound small cell carcinoma mixed with squamous cell carcinoma and true small cell carcinoma. Small cell type SCC lacks the nuclear characteristics of small cell carcinoma, that is, it has rough or vesicular chromatin, more obvious nucleolus, richer cytoplasm and clearer cell boundaries. Intercellular bridges or keratinization can be seen locally. The basal-like type can show obvious nuclei arranged in a fence shape. Poorly differentiated lung cancer with a broad basal-like growth pattern but lacking squamous differentiation characteristics can be considered a basal-like large cell carcinoma.

　　 is distinguished from large cell carcinoma based on the presence or absence of squamous differentiation. There may be intracellular mucin locally. Even if the invasive growth is not confirmed, the diagnosis of papillary SCC can be confirmed if there is obvious cell atypia. Small biopsy specimens should show caution when diagnosing well-differentiated papillary squamous epithelium, because the distinction between papillary squamous cell carcinoma and papilloma is difficult. Verrucous carcinoma of the lung is very rare and is included in papillary squamous cell carcinoma. Extensive invasion of the anterior mediastinum tissue can make the differential diagnosis with thymic squamous cell carcinoma difficult, and needs to be combined with the results of surgery and radiology. In the lung interstitium, squamous cell carcinoma can be surrounded by alveolar cells, and sometimes it can be misdiagnosed as adenosquamous carcinoma. The presence of squamous metaplasia with atypical cells in diffuse alveolar destruction (DAD) should consider the possibility of squamous cell carcinoma. The general characteristics of DAD, such as transparent membrane, diffuse alveolar septal connective tissue hyperplasia with alveolar cell hyperplasia and bronchiole central squamous, etc., are conducive to consider DAD as a metaplastic pathological process.