The prognosis of patients with different neuroblastomas varies greatly, that is, there is extensive tumor heterogeneity between neuroblastomas. According to different high-risk factors, neuroblastoma can be divided into low-risk group, medium-risk group and high-risk group. For patients with low-risk group neuroblastoma (most commonly in infants and young children), simple observation or surgical treatment can often achieve good results.

< p>　　However, in patients with high-risk group of neuroblastoma, even with a variety of intensive treatment options, the prognosis is still not ideal. Olfactory groove neuroblastoma is generally thought to originate from the olfactory nerve epithelium; its classification is still controversial. Because it does not belong to the sympathetic nervous system, olfactory groove neuroblastoma should belong to an independent type of tumor, which is different from the neuroblastoma described below.

　　Symptoms and signs: The initial symptoms of neuroblastoma are not typical, so early diagnosis is difficult. More common symptoms include fatigue, loss of appetite, fever and joint pain. The symptoms caused by a tumor depend on the organ in which the tumor is located and whether it has metastasized.

　　Most neuroblastomas (50-60％) have undergone extensive metastasis before clinical manifestations. The most common site of primary neuroblastoma is the adrenal glands (approximately 40％).

　　 Other primary organs include neck (1％), thoracic cavity (19％), abdominal cavity (30％), and pelvic cavity (1％). In other rare cases, the primary lesion could not be found. Rare but characteristic clinical manifestations include transverse spinal cord lesions (spinal cord compression, accounted for 5％), Refractory diarrhea (tumor secretes vasoactive intestinal peptide, accounting for 4％), Horner syndrome (neck tumor, accounting for 2.4％), ataxia (due to paracrine tumors, accounting for 1.3％), and hypertension (renal artery compression or catecholamine secretion, accounting for 1.3％).

　　Celiac neuroblastoma generally presents with abdominal distension and constipation, thoracic neuroblastoma generally presents with dyspnea, and spinal neuroblastoma generally presents with reduced trunk and limb strength. Patients often have Difficulties in standing and walking; neuroblastomas of bones such as legs and hips can manifest as bone pain and lameness; destruction of bone marrow can make patients'' skin pale due to anemia.