What is adrenocortical carcinoma? A malignant tumor that occurs in the adrenal cortex is called adrenocortical carcinoma. Children under 12 years old are relatively common, and only a few occur in adults.

　　pathological changes: (1) naked eye Observation: The tumor volume is generally large, often above 100g, even up to 1000g, showing aggressive growth, unclear state, brown or polychromatic cut surface, soft quality, often bleeding, necrosis and cystic changes ; (2) Microscopy: the poorly differentiated tumor cells have large atypia, and multinuclear tumor giant cells and mitotic images are often seen; well-differentiated like adenoma, if the tumor is small and has an envelope, it is difficult to distinguish it from adenoma. The difference between the two can be referred to the following points: ① cortical cancer often has extensive bleeding and necrosis, and adenoma rarely has necrosis; ② those who damage the capsule, invade blood vessels and surrounding tissues are generally cancer; ③ there are many mitotic images, greater than 2/ 10 high-powered fields are mostly malignant, and adenoma has few nuclear divisions; ④ carcinoma has extensive and obvious nuclear atypia, multinuclear tumor giant cells, larger nucleoli and inclusions in the nucleus; ⑤ tumor volume and weight have certain reference Value, the diameter of adenoma is mostly below 5cm, and the weight is less than 50g.
　　Adrenal cortical cancer is mostly functional, and often shows female virilization and adrenal hyperfunction, and is prone to local infiltration and metastasis. If there is lymphatic and bloodway spread, the average survival time is 2 years. The identification of functional and non-functional adrenal cortical tumors mainly depends on clinical manifestations, biochemical and hormone determination.