Cancer is the leading cause of death in the population of less than 85 years old in developed countries, and the cancer incidence and mortality rate in our country have also increased year by year. In 2002, 25 million cancer cases were reported globally, with China accounting for 20.3％ 7 million cancer-related deaths and China accounting for 23.8％ Among many cancers, lung cancer has the highest morbidity and mortality. The 5-year survival rate of lung cancer patients reported in the United States is only 16%.

　　 Therefore, when the treatment of advanced malignant tumors is slow, we should invest more medical resources in the early diagnosis of cancer to give patients more effective treatment before the cancer progresses to the advanced stage. So that patients can achieve a longer survival period and improve the overall survival rate of lung cancer. In an ideal state, the method of clinical screening to diagnose cancer requires simple, fast, accurate and reasonable cost. For example, a specific index can be detected from the blood to make a diagnosis.

　　Unfortunately, the current clinical tumor markers are organ-specific except for prostate specific antigen (PSA) and human chorionic gonadotropin (HCG), most of the others are Relevance is all expressed in general. And many tumor markers can only detect the increase in blood concentration when the disease progresses to the advanced stage, and there is no value for early diagnosis.

　　 Therefore, searching for a feasible, effective, and specific diagnosis of cancer and prognostic markers in the early clinical stage has become a hot spot in the research of tumor molecular biology. Most patients with lung cancer have lost the chance of surgical cure when diagnosed, which is the main reason for the low long-term survival rate of lung cancer.

　　Early screening is the key to improving the overall survival rate of lung cancer. The seven autoantibody profiles of serum lung cancer have the characteristics of minimally invasive, high sensitivity, high specificity and good stability, and are the first choice for early screening of patients with long-term smoking history and family history of lung cancer. A case of early lung cancer was found, saving a life and saving a family.