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Is malignant pheochromocytoma serious?

BY Iris Wheatley 2020-07-20

  Is malignant pheochromocytoma serious? The incidence of malignant pheochromocytoma is very low, and it is rarely seen in the clinic, but its severity and harmfulness are very large and belong to a rare type. Malignant tumors, patients with this disease often show symptoms of hypertension and metabolism, so it is easy to be misdiagnosed and mistreated, delaying the best time for treatment. Originoo_42964_24839581_l.jpg

Principles for the treatment of malignant pheochromocytoma:

  (1) Surgical resection is the main method for the treatment of malignant pheochromocytoma. Recurrence and metastasis should be treated as much as possible Resection to reduce tumor burden and relieve symptoms, but blood pressure should be paid attention to before, during, and after surgery, and accidents such as sudden death should be avoided as much as possible.

   (2) Radiation therapy for malignant pheochromocytoma is slightly sensitive to radiotherapy and can be used as appropriate.

   (3) Radioisotope treatment The tumor is highly sensitive (85%) and specific (100%) to 131I-MIBG imaging, so it is treated with a larger dose (200mCi in 5mg) Relapsed and metastatic malignant pheochromocytoma, but the efficacy is not satisfactory. As Feldman et al. (1984) reported that only 5 of the 12 cases had a decrease in catecholamine levels and only 2 cases of tumor shrinkage.

   (4) The effective rate of CTX+VCR+DTIC for the treatment of metastatic neuroblastoma is 80% this scheme is also effective for metastatic pheochromocytoma.

   Surgical resection of pheochromocytoma is the most effective treatment, but surgery has certain risks. The squeezing of the tumor during anesthesia and surgery is very easy to cause blood pressure fluctuations; the tumor is rich in blood and close to the large blood vessels, which is likely to cause massive bleeding. Therefore, correct treatment before, during and after surgery is extremely important.

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