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Is adrenal medulla tumor serious?

BY Iris Wheatley 2020-07-24

Is   adrenal medulla tumor serious? The adrenal gland is an important endocrine gland in the human body, which plays a very important role in regulation and control, but the more important parts are more susceptible to disease invasion, adrenal medulloma is relatively rare in our daily life It is rarely heard, but its harmfulness should not be underestimated. So, is adrenal medulloma serious?

  Adrenal medullary adenoma is a tumor that occurs in the chromaffin tissue of the adrenal medulla, sympathetic ganglia, parasympathetic ganglia, or other parts. This kind of tumor continuously or indirectly releases a large amount of catecholamines, causing endocrine disease with onset hypertension and sympathetic nerve excitation as the main clinical manifestation. Severe attacks can cause cardiovascular and cerebrovascular accidents and endanger the patient''s life.

  If diagnosed early, benign adrenal medullary adenoma can be cured by surgery. The disease is a rare secondary hypertension, with a prevalence rate of 0.1%~1%. In recent years, with the development of medicine and the increased vigilance of doctors, the discovery of this disease has gradually increased. The incidence of men and women is similar, and it can occur in all age groups. ~50 years old is the most common, there are many children patients.

  Pediatric patients have a male to female ratio of 2:1. The disease may have a family history and is called familial adrenal medullary adenoma. It belongs to type Ⅱ and Ⅲ in multiple endocrine adenoma. 80%~90%, malignant account for 10%~2 0%. The diameter of the tumor is about 12 to 16 cm, the weight ranges from several grams to 3 kg, and the size varies, generally around 100 grams.

  Approximately 80% Adrenal medullary adenoma is found in the adrenal medulla, but it can also be found in other tissues from neurospinal cells. The adrenal medullary tumor is equal in both sexes, bilateral 10%(Child 20& #xFF05;), usually benign (95%), extraadrenal tumors are more malignant (30%), although adrenal medullary adenoma can be seen at any age, but the maximum incidence is between 20-50 years.

  The clinical manifestations are caused by tumor cells secreting large amounts of catecholamines. Adrenal pheochromocytoma mainly secretes epinephrine. The pheochromocytoma outside the adrenal gland mainly secretes norepinephrine, which is due to the lack of methyl transferase in ectopic tumor tissue. Catecholamines secreted by pheochromocytoma can be intermittent or continuous, resulting in variable clinical symptoms.

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