Pulmonary cancer experts recommend that adults should have a health check-up every year, early detection and early treatment, then, how can ordinary people judge whether their lungs are the first time for various unfamiliar medical terms in the physical examination? Suffering from cancer? How do you understand the lung cancer examination report?

　　What are the common lung cancer tumor markers?

　　According to the World Health Organization ( WHO) pathological analysis, lung cancer is divided into two main tissue types: small cell lung cancer and non-small cell lung cancer, of which more than 80% of patients are non-small cell lung cancer.

　　 Medically, the two types of lung cancer correspond to different types of tumor markers:

　　(1) Small cell lung cancer

　　small cell carcinoma, also known as oat cell carcinoma, has a high degree of clinical malignancy and a poor prognosis. The related tumor markers are: NSE, ProGRP, CA125, Cyfra21-1, CA153.

　　(2) Non-small cell lung cancer

　　Non-small cell lung cancer is a high-incidence type of lung cancer, which can be generally divided into squamous cell carcinoma, adenocarcinoma and gland Mixed squamous cell carcinoma, etc. The relevant markers are: CEA, Cyfra21-1, CA125, CA153, TPA and SCC-Ag.

　　The meaning behind the value of each tumor marker in the report?

　　(1) CEA (positive standard ≥5ng/ml)< /strong>

　　CEA is a broad-spectrum tumor marker. Although it cannot be used as a specific indicator for the diagnosis of lung cancer, it has important clinical value in the differential diagnosis of lung cancer. If the CEA value in the medical report is greater than or equal to the positive standard, the possibility of malignant tumors can be further considered. In clinical practice, lung adenocarcinoma has the highest CEA value, with a positive rate of 55 percent.

　　(2) Cyfra21-1( Positive standard ≥3.3ng/ml )

　　Cyfra21-1 is an acidic peptide, water soluble cytokeratin , Mainly distributed in the alveolar epithelium. When alveolar epithelial cells become cancerous, Cyfra21-1 can be released into the blood circulation, resulting in increased serum levels of Cyfra21-1. Cyfra21-1 is currently the preferred tumor marker for squamous cell carcinoma, with sensitivity up to 60% and specificity up to 95%. It has important significance for the early diagnosis, curative effect monitoring and prognosis judgment of non-small cell lung cancer.

　　(3) CA125 (positive standard ≥20u/ml)

　　CA125 is recognized by monoclonal antibody OC125 produced by immune ovarian cancer cell line The antigenic determinant is the same as OC125, a molecule recognized by immune lung adenocarcinoma cells, so CA125 is an antigen shared by ovarian and lung cancer cells. In other words, if the CA125 level meets or exceeds the positive standard, it can be considered as lung cancer. Among them, the CA125 level of lung adenocarcinoma was significantly higher than that of lung squamous cell carcinoma and small cell lung cancer.

　　(4) CA153

　　CA153 exists in various adenocarcinomas, such as breast cancer, lung adenocarcinoma, ovarian cancer and pancreatic cancer. Abnormally elevated serum CA153 can basically be judged as lung cancer with high specificity.

　　(5) TPA (tissue peptide antigen< 1 ng/ml)

　　 is used for the detection of squamous cell carcinoma such as lung squamous cell carcinoma, serum of malignant tumor The level of TPA can be significantly increased. TPA is currently the best tumor marker in the diagnosis and prognosis of lung squamous cell carcinoma. It should be noted that acute hepatitis, pancreatitis, pneumonia, pregnant women TPA can be increased in the last 3 months, we should pay attention to exclude interference factors.

　　(6) SCC-Ag (positive standard ≥1.5ng/ml)

　　SCC-Ag is caused by non-small cell lung cancer (especially lung scale Carcinoma) a glycoprotein secreted with low sensitivity, which can be used as an auxiliary diagnostic indicator for lung cancer.